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=== Antibiotics === | === Antibiotics === | ||
==== Penicillin ==== | ==== Penicillin ==== | ||
+ | ==== Griseofulvin ==== | ||
+ | Griseofulvin is an antifungal drug which is used both in animals and humans to treat fungal infections of the skin and nails and taken by orally. The most common skin infection is the ringworm. It is isolated from a Penicillium griseofulvum in 1939. | ||
+ | |||
+ | The drug disrupts the mitotic spindle through interacting with polymerized microtubules where inhibiting the mitosis. The cells get resistant to fungal infections when it binds to keratin in keratin precursor cells. The drug reaches its site of action only when the hair or skin is replaced by the keratin griseofulvin complex. Then the drug will bind to fungal microtubules by entering the dermatophyte through energy dependent transport process. Therefore, the process of mitosis changes and the original information for deposition of fungal cell walls. | ||
+ | |||
+ | Griseofulvin can also be a potential treatment for cancer. They use an unusual mechanism to confirm the correct genetic material is present within each of the resulting tumor cells when cancer cells divide, undergo mitosis. The most common side effects are nausea, diarrhea, headache, skin eruptions and photosensitivity. Hepatotoxicity and neurological side effects hardly occur. | ||
+ | |||
=== Immune-suppressants === | === Immune-suppressants === | ||
=== Toxins === | === Toxins === |
Revision as of 21:55, 16 March 2013
Secondary Metabolites of Fungi
Contents |
Definitions
Introduction
Species types involved
Pigments
Volatiles (odour)
Antibiotics
Penicillin
Griseofulvin
Griseofulvin is an antifungal drug which is used both in animals and humans to treat fungal infections of the skin and nails and taken by orally. The most common skin infection is the ringworm. It is isolated from a Penicillium griseofulvum in 1939.
The drug disrupts the mitotic spindle through interacting with polymerized microtubules where inhibiting the mitosis. The cells get resistant to fungal infections when it binds to keratin in keratin precursor cells. The drug reaches its site of action only when the hair or skin is replaced by the keratin griseofulvin complex. Then the drug will bind to fungal microtubules by entering the dermatophyte through energy dependent transport process. Therefore, the process of mitosis changes and the original information for deposition of fungal cell walls.
Griseofulvin can also be a potential treatment for cancer. They use an unusual mechanism to confirm the correct genetic material is present within each of the resulting tumor cells when cancer cells divide, undergo mitosis. The most common side effects are nausea, diarrhea, headache, skin eruptions and photosensitivity. Hepatotoxicity and neurological side effects hardly occur.
Immune-suppressants
Toxins
Steroids
Processes involved
History
References