Amanita phalloides
From BIOL 2P96 Jan 2013 Group 08
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- | The death cap, ''Amanita phalloides'', is a highly toxic fungus, ingestion of which can cause severe liver and kidney damage eventually resulting in death if left untreated. <sup>[http://www.anbg.gov.au/fungi/deathcap.html]</sup> This is due to the high content of α- and β-amanitin. <sup>[http://www.ncbi.nlm.nih.gov/pubmed/20954964]</sup> | + | The death cap, ''Amanita phalloides'', is a highly toxic fungus, ingestion of which can cause severe liver and kidney damage eventually resulting in death if left untreated. <sup>[http://www.anbg.gov.au/fungi/deathcap.html]</sup> This is due to the high content of the α- and β-amanitin peptides. <sup>[http://www.ncbi.nlm.nih.gov/pubmed/20954964]</sup> |
+ | ==Mode of Biological Action== | ||
+ | Both α- and β-amanitin function as RNA polymerase II inhibitors, binding to the active site pocket and preventing the translation of DNA into RNA.<sup>[http://www.reproduction-online.org/content/98/1/195.abstract]</sup> Thus protein synthesis is stalled, eventually resulting in cell death. |
Revision as of 01:38, 22 March 2013
The death cap, Amanita phalloides, is a highly toxic fungus, ingestion of which can cause severe liver and kidney damage eventually resulting in death if left untreated. [1] This is due to the high content of the α- and β-amanitin peptides. [2]
Mode of Biological Action
Both α- and β-amanitin function as RNA polymerase II inhibitors, binding to the active site pocket and preventing the translation of DNA into RNA.[3] Thus protein synthesis is stalled, eventually resulting in cell death.